vitamin K-antagonist embryofetopathy
MONDO:0016010Mondo
Findings
No curated finding names vitamin K-antagonist embryofetopathy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A teratogenic disorder observed in a newborn or child of a mother who was exposed to warfarin during pregnancy. Manifestations include nasal bridge depression, nasal bones hypoplasia, microcephaly, congenital heart disorders, and brachydactyly.
Definition from the Mondo Disease Ontology (MONDO:0016010), read 2026-09-29. CC BY 4.0.
Features
26 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Anteverted naresHPOHP:0000463
- Very frequent (80% to 99% of cases)
- Depressed nasal bridgeHPOHP:0005280
- Very frequent (80% to 99% of cases)
- Epiphyseal stipplingHPOHP:0010655
- Very frequent (80% to 99% of cases)
- Punctate vertebral calcificationsHPOHP:0008420
- Very frequent (80% to 99% of cases)
- Short noseHPOHP:0003196
- Very frequent (80% to 99% of cases)
- BrachydactylyHPOHP:0001156
- Frequent (30% to 79% of cases)
- Intellectual disabilityHPOHP:0001249
- Frequent (30% to 79% of cases)
- Intrauterine growth retardationHPOHP:0001511
- Frequent (30% to 79% of cases)
- Respiratory insufficiencyHPOHP:0002093
- Frequent (30% to 79% of cases)
- Short distal phalanx of fingerHPOHP:0009882
- Frequent (30% to 79% of cases)
- Short neckHPOHP:0000470
- Frequent (30% to 79% of cases)
- Abnormal cardiovascular system morphologyHPOHP:0030680
- Occasional (5% to 29% of cases)
Show the remaining 14
- Aplasia/Hypoplasia affecting the eyeHPOHP:0008056
- Occasional (5% to 29% of cases)
- CataractHPOHP:0000518
- Occasional (5% to 29% of cases)
- Choanal atresiaHPOHP:0000453
- Occasional (5% to 29% of cases)
- Hearing impairmentHPOHP:0000365
- Occasional (5% to 29% of cases)
- HydrocephalusHPOHP:0000238
- Occasional (5% to 29% of cases)
- HypertelorismHPOHP:0000316
- Occasional (5% to 29% of cases)
Where it sits
Other names
9 names
Resolves to: vitamin K-antagonist embryofetopathy
- Also called
- di Sala syndromefetal Coumadin syndromefetal warfarin syndromefoetal Coumadin syndromefoetal warfarin syndromevitamin K antagonist embryopathyvitamin K-antagonist embryopathywarfarin embryofetopathywarfarin embryopathy