VIPoma
MONDO:0019960Mondo
Findings
No curated finding names VIPoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
VIPoma is an extremely rare type of pancreatic neuroendocrine tumor that secretes vasoactive intestinal polypeptide (VIP) leading to the manifestations of watery diarrhea, hypokalemia and achlorhydia or hypochhlorhydia (known as WDHA syndrome).
Definition from the Mondo Disease Ontology (MONDO:0019960), read 2026-09-29. CC BY 4.0.
Features
40 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HypokalemiaHPOHP:0002900
- Very frequent (80% to 99% of cases)
- Neoplasm of the pancreasHPOHP:0002894
- Very frequent (80% to 99% of cases)
- Secretory diarrheaHPOHP:0005208
- Very frequent (80% to 99% of cases)
- AnorexiaHPOHP:0002039
- Frequent (30% to 79% of cases)
- Chronic fatigueHPOHP:0012432
- Frequent (30% to 79% of cases)
- DehydrationHPOHP:0001944
- Frequent (30% to 79% of cases)
- Diabetes mellitusHPOHP:0000819
- Frequent (30% to 79% of cases)
- Episodic abdominal painHPOHP:0002574
- Frequent (30% to 79% of cases)
- ErythemaHPOHP:0010783
- Frequent (30% to 79% of cases)
- Generalized muscle weaknessHPOHP:0003324
- Frequent (30% to 79% of cases)
- HepatomegalyHPOHP:0002240
- Frequent (30% to 79% of cases)
- HypercalcemiaHPOHP:0003072
- Frequent (30% to 79% of cases)
Reported absent (1)
- HematocheziaHPOHP:0002573
Show the remaining 28
- MalabsorptionHPOHP:0002024
- Frequent (30% to 79% of cases)
- Muscle spasmHPOHP:0003394
- Frequent (30% to 79% of cases)
- Nausea and vomitingHPOHP:0002017
- Frequent (30% to 79% of cases)
- Normochromic anemiaHPOHP:0001895
- Frequent (30% to 79% of cases)
- Poor appetiteHPOHP:0004396
- Frequent (30% to 79% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
18 names
Resolves to: VIPoma
- Also called
- Diarrheogenic islet cell tumorDiarrheogenic islet cell tumourmalignant vasoactive intestinal peptide-secreting tumourvasoactive intestinal peptide producing neoplasmvasoactive intestinal peptide producing tumorvasoactive intestinal peptide producing tumourvasoactive intestinal peptide secreting neoplasmvasoactive intestinal peptide-secreting tumourVerner-Morrison syndromeVIP producing neoplasmVIP- secreting neoplasmVIP- secreting tumorVIP- secreting tumourVIP-producing NETVIP-producing neuroendocrine tumor