tropical spastic paraparesis
Findings
No curated finding names tropical spastic paraparesis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.
Definition from the Mondo Disease Ontology (MONDO:0008039), read 2026-09-29. CC BY 4.0.
Features
2 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, hp/releases/2026-09-01.
- Muscle stiffnessMondoHP:0003552
- Muscle weaknessMondoHP:0001324
Where it sits
Other names
6 names
Resolves to: tropical spastic paraparesis
- Also called
- HAM/TSPHTLV-1-associated myelopathy/tropical spastic paraparesisHuman T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesisHuman T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesistropical spastic paraplegiaTSP