tropical endomyocardial fibrosis
Findings
No curated finding names tropical endomyocardial fibrosis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Tropical endomyocardial fibrosis is a restrictive cardiopathy, occurring almost exclusively in children and young adults in tropical and subtropical regions, characterized by endocardial fibrosis, affecting the apices and the inflow tract of the right or left ventricle (or both) and manifesting with a restrictive cardimyopathy and atrioventricular regurgitation leading to severe pulmonary hypertension, very high systemic venous pressure and congestive cardiac failure. Suspected etiologies include helminth and protozoal infestation and malnutrition.
Definition from the Mondo Disease Ontology (MONDO:0019158), read 2026-09-29. CC BY 4.0.
Features
48 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Endocardial fibrosisHPOHP:0006685
- Obligate (100% of cases)
- Abnormal EKGHPOHP:0003115
- Very frequent (80% to 99% of cases)
- DyspneaHPOHP:0002094
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- Restrictive cardiomyopathyHPOHP:0001723
- Very frequent (80% to 99% of cases)
- Abnormal ST segmentHPOHP:0012249
- Frequent (30% to 79% of cases)
- ArrhythmiaHPO
Show the remaining 36
- Decreased QRS voltageHPOHP:0025077
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- HepatomegalyHPOHP:0002240
- Frequent (30% to 79% of cases)
- HypoalbuminemiaHPOHP:0003073
- Frequent (30% to 79% of cases)
- Left atrial enlargementHPOHP:0031295
- Frequent (30% to 79% of cases)
- Left bundle branch blockHPOHP:0011713
- Frequent (30% to 79% of cases)
Where it sits
Other names
2 names
Resolves to: tropical endomyocardial fibrosis
- Also called
- Davies diseaseTEMF