toxic shock syndrome
Findings
No curated finding names toxic shock syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare acute life-threatening systemic bacterial noncontagious illness caused by exotoxins from bacteria of either the Streptococcus pyogenes or Staphylococcus aureus type. It is characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria.
Definition from the Mondo Disease Ontology (MONDO:0001881), read 2026-09-29. CC BY 4.0.
Features
61 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- HypotensionHPO · MondoHP:0002615
- Very frequent (80% to 99% of cases)
- Severe infectionHPOHP:0032169
- Very frequent (80% to 99% of cases)
- ShockHPOHP:0031273
- Very frequent (80% to 99% of cases)
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- Abnormality of facial soft tissueHPOHP:0011799
- Frequent (30% to 79% of cases)
- ConfusionHPOHP:0001289
- Frequent (30% to 79% of cases)
- Fasciitis
Show the remaining 49
- Recurrent skin infectionsHPOHP:0001581
- Frequent (30% to 79% of cases)
- Respiratory distressHPOHP:0002098
- Frequent (30% to 79% of cases)
- TachycardiaHPOHP:0001649
- Frequent (30% to 79% of cases)
- Abnormal blistering of the skinHPOHP:0008066
- Occasional (5% to 29% of cases)
- Abnormality of the lower limbHPOHP:0002814
- Occasional (5% to 29% of cases)
- Abnormality of the upper limbHPOHP:0002817
- Occasional (5% to 29% of cases)
Where it sits
- Narrower terms (2)
Other names
7 names
Resolves to: toxic shock syndrome
- Also called
- bacterial toxic-shock syndromebacterial TSSshock syndrome (TSS), toxicsyndrome (TSS), toxic shocktoxic shock syndrome, (TSS)TSSTSS, toxic shock syndrome