thyrotoxic periodic paralysis
MONDO:0019201Mondo
Findings
No curated finding names thyrotoxic periodic paralysis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Thyrotoxic periodic paralysis (TPP) is a rare neurological disease characterized by recurrent episodes of paralysis and hypokalemia during a thyrotoxic state.
Definition from the Mondo Disease Ontology (MONDO:0019201), read 2026-09-29. CC BY 4.0.
Features
39 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Episodic hypokalemiaHPOHP:0012726
- Obligate (100% of cases)
- HyperthyroidismHPOHP:0000836
- Obligate (100% of cases)
- Periodic hypokalemic paresisHPOHP:0008153
- Obligate (100% of cases)
- Abnormal muscle fiber morphologyHPOHP:0004303
- Very frequent (80% to 99% of cases)
- Decreased urinary potassiumHPOHP:0012364
- Very frequent (80% to 99% of cases)
- EMG abnormalityHPOHP:0003457
- Very frequent (80% to 99% of cases)
- Episodic flaccid weaknessHPOHP:0003752
- Very frequent (80% to 99% of cases)
- Graves diseaseHPOHP:0100647
- Very frequent (80% to 99% of cases)
- HyperhidrosisHPOHP:0000975
- Very frequent (80% to 99% of cases)
- HypomagnesemiaHPOHP:0002917
- Very frequent (80% to 99% of cases)
- HypophosphatemiaHPOHP:0002148
- Very frequent (80% to 99% of cases)
- Increased intramyocellular lipid dropletsHPOHP:0012240
- Very frequent (80% to 99% of cases)
Reported absent (3)
- Abnormality of peripheral nerve conductionHPOHP:0003134
- Impaired myocardial contractilityHPOHP:0006670
- MyotoniaHPOHP:0002486
Show the remaining 27
- Lower limb muscle weaknessHPOHP:0007340
- Very frequent (80% to 99% of cases)
- Mildly elevated creatine kinaseHPOHP:0008180
- Very frequent (80% to 99% of cases)
- ObesityHPOHP:0001513
- Very frequent (80% to 99% of cases)
- PalpitationsHPOHP:0001962
- Very frequent (80% to 99% of cases)
- ParalysisHPOHP:0003470
- Very frequent (80% to 99% of cases)
- TetraplegiaHPOHP:0002445
- Very frequent (80% to 99% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: thyrotoxic periodic paralysis
- Also called
- thyrotoxic hypokalemic periodic paralysis