thyroid gland undifferentiated (anaplastic) carcinoma
Findings
No curated finding names thyroid gland undifferentiated (anaplastic) carcinoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A primary carcinoma of the thyroid gland composed of undifferentiated cells. The malignant cells demonstrate evidence of epithelial differentiation, either by immunohistochemistry or electron microscopic studies. Microscopically, in the majority of cases there is a mixture of spindle, epithelioid, and giant cells. The vast majority of the patients present with a rapidly enlarging neck mass. The clinical course is usually aggressive.
Definition from the Mondo Disease Ontology (MONDO:0006468), read 2026-09-29. CC BY 4.0.
Features
23 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Anaplastic thyroid carcinomaHPOHP:0011779
- Obligate (100% of cases)
- Broad neckHPOHP:0000475
- Very frequent (80% to 99% of cases)
- GoiterHPOHP:0000853
- Very frequent (80% to 99% of cases)
- Hoarse voiceHPOHP:0001609
- Very frequent (80% to 99% of cases)
- Nodular goiterHPOHP:0005994
- Very frequent (80% to 99% of cases)
- DysphagiaHPOHP:0002015
- Frequent (30% to 79% of cases)
- Laryngotracheal stenosisHPO
Show the remaining 11
- Vocal cord paralysisHPOHP:0001605
- Frequent (30% to 79% of cases)
- Abnormal skeletal muscle morphologyHPOHP:0011805
- Occasional (5% to 29% of cases)
- CoughHPOHP:0012735
- Occasional (5% to 29% of cases)
- DysphoniaHPOHP:0001618
- Occasional (5% to 29% of cases)
- DyspneaHPOHP:0002094
- Occasional (5% to 29% of cases)
- HemoptysisHPOHP:0002105
- Occasional (5% to 29% of cases)
Where it sits
Other names
23 names
Resolves to: thyroid gland undifferentiated (anaplastic) carcinoma
- Also called
- anaplastic carcinoma of the thyroidanaplastic carcinoma of the thyroid glandanaplastic carcinoma of thyroidanaplastic carcinoma of thyroid glandanaplastic thyroid canceranaplastic thyroid carcinomaanaplastic thyroid gland carcinomaDedifferentiated thyroid gland carcinomametaplastic thyroid gland carcinomapleomorphic thyroid gland carcinomasarcomatoid thyroid gland carcinomathyroid gland carcinosarcomathyroid gland undifferentiated carcinomaundifferentiated (anaplastic) thyroid gland cancerundifferentiated (anaplastic) thyroid gland carcinoma