tenosynovial giant cell tumor, diffuse type
Findings
No curated finding names tenosynovial giant cell tumor, diffuse type yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A locally aggressive, diffusely infiltrating tumor, arising in the tendon sheath. It is composed of synovial-like mononuclear cells, hemosiderin-laden macrophages, foam cells, and inflammatory cells. Multinucleated osteoclast-like giant cells are usually present, although in a minority of cases they may be absent or rare. It predominantly affects young adults. Symptoms include joint swelling, pain, and joint effusion.
Definition from the Mondo Disease Ontology (MONDO:0024686), read 2026-09-29. CC BY 4.0.
Features
24 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ArthralgiaHPOHP:0002829
- Very frequent (80% to 99% of cases)
- Abnormality of the kneeHPOHP:0002815
- Frequent (30% to 79% of cases)
- ArthritisHPOHP:0001369
- Frequent (30% to 79% of cases)
- Joint hemorrhageHPOHP:0005261
- Frequent (30% to 79% of cases)
- Joint stiffnessHPOHP:0001387
- Frequent (30% to 79% of cases)
- Joint swellingHPOHP:0001386
- Frequent (30% to 79% of cases)
- Limitation of joint mobilityHPO
Show the remaining 12
- Abnormal tympanic membrane morphologyHPOHP:0040090
- Occasional (5% to 29% of cases)
- Abnormality of the ankleHPOHP:0003028
- Occasional (5% to 29% of cases)
- Abnormality of the elbowHPOHP:0009811
- Occasional (5% to 29% of cases)
- Abnormality of the wristHPOHP:0003019
- Occasional (5% to 29% of cases)
- Conductive hearing impairmentHPOHP:0000405
- Occasional (5% to 29% of cases)
- Groin painHPOHP:0031520
- Occasional (5% to 29% of cases)
Where it sits
Other names
15 names
Resolves to: tenosynovial giant cell tumor, diffuse type
- Also called
- diffuse giant cell neoplasm of tendon sheathdiffuse giant cell neoplasm of Tenosynoviumdiffuse giant cell neoplasm of the Tenosynoviumdiffuse giant cell tumor of tendon sheathdiffuse giant cell tumor of Tenosynoviumdiffuse giant cell tumor of the Tenosynoviumdiffuse giant cell tumour of tendon sheathdiffuse giant cell tumour of Tenosynoviumdiffuse giant cell tumour of the Tenosynoviumdiffuse tenosynovial giant cell neoplasmdiffuse tenosynovial giant cell tumordiffuse tenosynovial giant cell tumourpigmented villonodular synovitisTGCT