T-B- severe combined immunodeficiency
MONDO:0017855Mondo
Findings
No curated finding names T-B- severe combined immunodeficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
T-B- severe combined immunodeficiency (SCID) is a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T and B lymphocytes, resulting in recurrent early-onset severe respiratory viral, bacterial or fungal infections, diarrhea and failure to thrive. Hypersensitivity to ionizing radiation is a characteristic feature of some of its sub-types.
Definition from the Mondo Disease Ontology (MONDO:0017855), read 2026-09-29. CC BY 4.0.
Where it sits
- A kind of
- Narrower terms (16)
- Cernunnos-XLF deficiency
- combined immunodeficiency due to partial RAG1 deficiency
- combined immunodeficiency with skin granulomas
- DNA ligase IV deficiency
- immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia
- immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia
- neutrophil immunodeficiency syndrome
- Omenn syndrome
- reticular dysgenesis
- reticular dysgenesis-like severe combined immunodeficiency
- severe combined immunodeficiency due to DCLRE1C deficiency
- severe combined immunodeficiency due to DNA-PKcs deficiency
- severe combined immunodeficiency due to LCK deficiency
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency
- severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive
- short-limb skeletal dysplasia with severe combined immunodeficiency
Other names
1 name
Resolves to: T-B- severe combined immunodeficiency
- Also called
- T-B- SCID