sweet syndrome
Findings
No curated finding names sweet syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Sweet's syndrome (the eponym for acute febrile neutrophilic dermatosis) is characterized by a constellation of clinical symptoms, physical features, and pathologic findings which include fever, neutrophilia, tender erythematous skin lesions (papules, nodules, and plaques), and a diffuse infiltrate consisting predominantly of mature neutrophils that are typically located in the upper dermis.
Definition from the Mondo Disease Ontology (MONDO:0011959), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Childhood onset
HPO, annotations 2026-09-02
Features
42 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- ArthralgiaHPOHP:0002829
- 12 of 12 reported patients
- Frequent (30% to 79% of cases)
- Cystic acneHPOHP:0033188
- 3 of 3 reported patients
- MyalgiaHPOHP:0003326
- 12 of 12 reported patients
- Frequent (30% to 79% of cases)
- Recurrent feverHPOHP:0001954
- 13 of 15 reported patients
- Elevated circulating C-reactive protein concentrationHPOHP:0011227
- 11 of 13 reported patients
- Frequent (30% to 79% of cases)
- Pyoderma gangrenosumHPOHP:0025452
- 11 of 13 reported patients
- Occasional (5% to 29% of cases)
Show the remaining 30
- Abnormality of the faceHPOHP:0000271
- Frequent (30% to 79% of cases)
- Abnormality of the handHPOHP:0001155
- Frequent (30% to 79% of cases)
- Abnormality of the neckHPOHP:0000464
- Frequent (30% to 79% of cases)
- Abnormality of tumor necrosis factor secretionHPOHP:0011118
- Frequent (30% to 79% of cases)
- AcneHPOHP:0001061
- Frequent (30% to 79% of cases)
- Elevated erythrocyte sedimentation rateHPOHP:0003565
- 1 of 3 reported patients
Where it sits
Other names
1 name
Resolves to: sweet syndrome
- Also called
- acute febrile neutrophilic dermatosis