subacute cutaneous lupus erythematosus
MONDO:0015573Mondo
Findings
No curated finding names subacute cutaneous lupus erythematosus yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Subacute cutaneous lupus erythematosus (SCLE) is a form of cutaneous lupus erythematosus (CLE) that can present either as a non-scarring, annular photo-distributed dermatosis or psoriasiform plaques. SCLE is associated with anti-Ro/SSA antibodies and can be drug-induced.
Definition from the Mondo Disease Ontology (MONDO:0015573), read 2026-09-29. CC BY 4.0.
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Anti-Ro/SS-A antibody positivityHPOHP:0033555
- Very frequent (80% to 99% of cases)
- Annular cutaneous lesionHPOHP:0025528
- Frequent (30% to 79% of cases)
- Antinuclear antibody positivityHPOHP:0003493
- Frequent (30% to 79% of cases)
- Cutaneous photosensitivityHPOHP:0000992
- Frequent (30% to 79% of cases)
- Psoriasiform lesionHPOHP:0025526
- Frequent (30% to 79% of cases)
- Rheumatoid factor positiveHPOHP:0002923
- Frequent (30% to 79% of cases)
- Abnormal blistering of the skinHPOHP:0008066
- Occasional (5% to 29% of cases)
- Anti-dsDNA antibody positivityHPOHP:0020151
- Occasional (5% to 29% of cases)
- Anti-histone antibody positivityHPOHP:0033558
- Occasional (5% to 29% of cases)
- Anti-La/SS-B antibody positivityHPOHP:0032235
- Occasional (5% to 29% of cases)
- Antiphospholipid antibody positivityHPOHP:0003613
- Occasional (5% to 29% of cases)
- Dermal atrophyHPOHP:0004334
- Occasional (5% to 29% of cases)
Show the remaining 7
- Discoid lupus rashHPOHP:0007417
- Occasional (5% to 29% of cases)
- HyperkeratosisHPOHP:0000962
- Occasional (5% to 29% of cases)
- Linear C3 deposits along the epidermal basement membrane zoneHPOHP:0031541
- Occasional (5% to 29% of cases)
- Linear IgG deposits along the epidermal basement membrane zoneHPOHP:0031540
- Occasional (5% to 29% of cases)
- CheilitisHPOHP:0100825
- Very rare (1% to 4% of cases)
- Malar rashHPOHP:0025300
- Very rare (1% to 4% of cases)