sporadic adult-onset ataxia of unknown etiology
Findings
No curated finding names sporadic adult-onset ataxia of unknown etiology yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Sporadic adult-onset ataxia of unknown etiology describes a group of non-hereditary degenerative ataxias characterized by a slowly progressive cerebellar syndrome (with ataxia of stance and gait, upper limb dysmetria and intention tremor, ataxic speech, and oculomotor abnormalities), presenting in adulthood (at around 50 years of age), that is not due to a known cause. Extracerebellar symptoms (e.g., decreased vibration sense and absent or decreased ankle reflexes), polyneuropathy and mild autonomic dysfunction may also be present. Mild cognitive impairment has also rarely been reported.
Definition from the Mondo Disease Ontology (MONDO:0016591), read 2026-09-29. CC BY 4.0.
Features
28 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of eye movementHPOHP:0000496
- Very frequent (80% to 99% of cases)
- AtaxiaHPOHP:0001251
- Very frequent (80% to 99% of cases)
- Gait ataxiaHPOHP:0002066
- Very frequent (80% to 99% of cases)
- Abnormal autonomic nervous system physiologyHPOHP:0012332
- Frequent (30% to 79% of cases)
- Abnormal vestibulo-ocular reflexHPOHP:0007670
- Frequent (30% to 79% of cases)
- Cerebellar cortical atrophyHPOHP:0008278
- Frequent (30% to 79% of cases)
Show the remaining 16
- AkinesiaHPOHP:0002304
- Occasional (5% to 29% of cases)
- Babinski signHPOHP:0003487
- Occasional (5% to 29% of cases)
- DysarthriaHPOHP:0001260
- Occasional (5% to 29% of cases)
- DysdiadochokinesisHPOHP:0002075
- Occasional (5% to 29% of cases)
- DysphagiaHPOHP:0002015
- Occasional (5% to 29% of cases)
- HyperreflexiaHPOHP:0001347
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: sporadic adult-onset ataxia of unknown etiology
- Also called
- idiopathic late-onset cerebellar ataxiaSAOA