spontaneous periodic hypothermia
MONDO:0017577Mondo
Findings
No curated finding names spontaneous periodic hypothermia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Spontaneous periodic hypothermia (SPH) is a neurological disorder characterized by spontaneous periodic hypothermia and hyperhidrosis in the absence of hypothalamic lesions.
Definition from the Mondo Disease Ontology (MONDO:0017577), read 2026-09-29. CC BY 4.0.
Features
16 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AtaxiaHPOHP:0001251
- Very frequent (80% to 99% of cases)
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- Gait disturbanceHPOHP:0001288
- Very frequent (80% to 99% of cases)
- HyperhidrosisHPOHP:0000975
- Very frequent (80% to 99% of cases)
- HypothermiaHPOHP:0002045
- Very frequent (80% to 99% of cases)
- Nausea and vomitingHPOHP:0002017
- Very frequent (80% to 99% of cases)
- PallorHPOHP:0000980
- Very frequent (80% to 99% of cases)
- ArrhythmiaHPOHP:0011675
- Frequent (30% to 79% of cases)
- Reduced consciousnessHPOHP:0004372
- Frequent (30% to 79% of cases)
- SeizureHPOHP:0001250
- Frequent (30% to 79% of cases)
- Sleep disturbanceHPOHP:0002360
- Frequent (30% to 79% of cases)
- TremorHPOHP:0001337
- Frequent (30% to 79% of cases)
Show the remaining 4
- Abnormal pattern of respirationHPOHP:0002793
- Occasional (5% to 29% of cases)
- Aplasia/Hypoplasia of the corpus callosumHPOHP:0007370
- Occasional (5% to 29% of cases)
- DiarrheaHPOHP:0002014
- Occasional (5% to 29% of cases)
- Skin rashHPOHP:0000988
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: spontaneous periodic hypothermia
- Also called
- episodic spontaneous hypothermiaShapiro syndrome