spastic paraplegia, mitochondrial
MONDO:0975951Mondo
Findings
No curated finding names spastic paraplegia, mitochondrial yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Mitochondrial inheritance
- Onset and course
- Juvenile onset · Young adult onset · Childhood onset
HPO, annotations 2026-09-02
Features
17 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Babinski signHPOHP:0003487
- 10 of 10 reported patients
- Decreased motor nerve conduction velocityHPOHP:0003431
- 9 of 9 reported patients
- Decreased sensory nerve conduction velocityHPOHP:0003448
- 9 of 9 reported patients
- Gait disturbanceHPOHP:0001288
- 10 of 10 reported patients
- Hyperactive Achilles reflexHPOHP:0033206
- 10 of 10 reported patients
- Hyperactive patellar reflexHPOHP:0007083
- 10 of 10 reported patients
- Motor conduction blockHPOHP:0012078
- 9 of 9 reported patients
- Spastic paraplegiaHPOHP:0001258
- 10 of 10 reported patients
- Impaired distal vibration sensationHPOHP:0006886
- 8 of 10 reported patients
- Ankle clonusHPOHP:0011448
- 7 of 10 reported patients
- Hoffmann signHPOHP:0031993
- 7 of 10 reported patients
- Lower limb muscle weaknessHPOHP:0007340
- 7 of 10 reported patients
Show the remaining 5
- Knee clonusHPOHP:0011449
- 2 of 10 reported patients
- Abnormal fundus morphologyHPOHP:0001098
- 0 of 2 reported patients
- Abnormality of visual evoked potentialsHPOHP:0000649
- 0 of 2 reported patients
- Decreased number of large peripheral myelinated nerve fibersHPOHP:0003387
- 0 of 2 reported patients
- Hearing impairmentHPOHP:0000365
- 0 of 2 reported patients
Where it sits
- A kind of