Sjogren syndrome
Findings
No curated finding names Sjogren syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain
Definition from the Mondo Disease Ontology (MONDO:0010030), read 2026-09-29. CC BY 4.0.
Features
89 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Anti-Ro/SS-A antibody positivityHPOHP:0033555
- 53 of 60 reported patients
- Frequent (30% to 79% of cases)
- XerostomiaHPOHP:0000217
- 50 of 60 reported patients
- Very frequent (80% to 99% of cases)
- Keratoconjunctivitis siccaHPO · MondoHP:0001097
- 46 of 60 reported patients
- Very frequent (80% to 99% of cases)
- Abnormality of the kidneyHPOHP:0000077
- Frequent (30% to 79% of cases)
- Abnormality of the musculatureHPOHP:0003011
- Frequent (30% to 79% of cases)
- Abnormality of the nervous systemHPOHP:0000707
Show the remaining 77
- Chronic painHPOHP:0012532
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- ParotitisHPOHP:0011850
- Frequent (30% to 79% of cases)
- Polyarticular arthropathyHPOHP:0005195
- Frequent (30% to 79% of cases)
- Reduced circulating complement concentrationHPOHP:0004431
- Frequent (30% to 79% of cases)
- Tubulointerstitial nephritisHPOHP:0001970
- Frequent (30% to 79% of cases)
Where it sits
Other names
6 names
Resolves to: Sjogren syndrome
- Also called
- primary Sjogren-Gougerot syndromeprimary Sjögren-Gougerot syndromesicca syndromeSjögren syndromeSjögren-Gougerot syndromesyndrome, Sjogren's