simple cryoglobulinemia
MONDO:0019606Mondo
Findings
No curated finding names simple cryoglobulinemia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Simple (monoclonal) cryoglobulinemia or type I cryoglobulinemia refers to the presence in the serum of one isotype or subclass of immunoglobulin (Ig) that precipitates reversibly below 37°C.
Definition from the Mondo Disease Ontology (MONDO:0019606), read 2026-09-29. CC BY 4.0.
Features
55 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of blood and blood-forming tissuesHPOHP:0001871
- Very frequent (80% to 99% of cases)
- Cold urticariaHPOHP:0410135
- Very frequent (80% to 99% of cases)
- PurpuraHPOHP:0000979
- Very frequent (80% to 99% of cases)
- Acral ulcerationHPOHP:0006121
- Frequent (30% to 79% of cases)
- Distal peripheral sensory neuropathyHPOHP:0007067
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- Increased circulating IgM concentrationHPOHP:0003496
- Frequent (30% to 79% of cases)
- Livedo racemosaHPOHP:0033260
- Frequent (30% to 79% of cases)
- Localized skin lesionHPOHP:0011355
- Frequent (30% to 79% of cases)
- Multiple mononeuropathyHPOHP:0032018
- Frequent (30% to 79% of cases)
- ParaproteinemiaHPOHP:0031047
- Frequent (30% to 79% of cases)
- Peripheral neuropathyHPOHP:0009830
- Frequent (30% to 79% of cases)
Show the remaining 43
- Raynaud phenomenonHPOHP:0030880
- Frequent (30% to 79% of cases)
- Sensorimotor neuropathyHPOHP:0007141
- Frequent (30% to 79% of cases)
- Unexplained feversHPOHP:0001955
- Frequent (30% to 79% of cases)
- Abnormality of the kidneyHPOHP:0000077
- Occasional (5% to 29% of cases)
- ArthralgiaHPOHP:0002829
- Occasional (5% to 29% of cases)
- ArthritisHPOHP:0001369
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: simple cryoglobulinemia
- Also called
- cryoglobulinemia type 1