sick sinus syndrome 4
MONDO:0859173Mondo
Findings
No curated finding names sick sinus syndrome 4 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Childhood onset
HPO, annotations 2026-09-02
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Atrioventricular blockHPOHP:0001678
- 9 of 11 reported patients
- Sinus bradycardiaHPOHP:0001688
- 5 of 11 reported patients
- Paroxysmal atrial fibrillationHPOHP:0004757
- 3 of 11 reported patients
- SyncopeHPOHP:0001279
- 3 of 11 reported patients · Young adult onset
- Chronotropic incompetenceHPOHP:0033992
- 2 of 11 reported patients
- Sinoatrial blockHPOHP:0012723
- 1 of 11 reported patients
- Abnormal PR intervalHPOHP:0031593
- 0 of 11 reported patients
- Abnormal QRS complexHPOHP:0025074
- 0 of 11 reported patients
- Abnormal QT intervalHPOHP:0031547
- 0 of 11 reported patients
- Sudden cardiac deathHPOHP:0001645
- 0 of 11 reported patients
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- GNB2HGNC:4398
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2021
Where it sits
- A kind of