Shwartzman phenomenon
Findings
No curated finding names Shwartzman phenomenon yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (endotoxins) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous thrombosis and necrosis. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of immune system, coagulation, fibrinolysis, and blood flow.
Definition from the Mondo Disease Ontology (MONDO:0002783), read 2026-09-29. CC BY 4.0.
Where it sits
Other names
1 name
Resolves to: Shwartzman phenomenon
- Also called
- Shwartzman reaction (function)