Shiga toxin-associated hemolytic uremic syndrome
MONDO:0019536Mondo
Findings
No curated finding names Shiga toxin-associated hemolytic uremic syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare thrombotic microangiopathy characterized by mechanical hemolytic anemia, thrombocytopenia, and renal dysfunction that is usually associated with prodromal enteritis caused by Shigella dysentriae type 1 or E. Coli.
Definition from the Mondo Disease Ontology (MONDO:0019536), read 2026-09-29. CC BY 4.0.
Features
33 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- Acute kidney injuryHPOHP:0001919
- Frequent (30% to 79% of cases)
- AnuriaHPOHP:0100519
- Frequent (30% to 79% of cases)
- DiarrheaHPOHP:0002014
- Frequent (30% to 79% of cases)
- Dysfunctional alternative complement pathwayHPOHP:0005423
- Frequent (30% to 79% of cases)
- Elevated circulating creatinine concentrationHPOHP:0003259
- Frequent (30% to 79% of cases)
- Microangiopathic hemolytic anemiaHPOHP:0001937
- Frequent (30% to 79% of cases)
- ThrombocytopeniaHPOHP:0001873
- Frequent (30% to 79% of cases)
- Unconjugated hyperbilirubinemiaHPOHP:0008282
- Frequent (30% to 79% of cases)
- VomitingHPOHP:0002013
- Frequent (30% to 79% of cases)
- Abnormality of the nervous systemHPOHP:0000707
- Occasional (5% to 29% of cases)
- Acute colitisHPOHP:0100282
- Occasional (5% to 29% of cases)
Show the remaining 21
- Bloody diarrheaHPOHP:0025085
- Occasional (5% to 29% of cases)
- DehydrationHPOHP:0001944
- Occasional (5% to 29% of cases)
- Excessive daytime somnolenceHPOHP:0001262
- Occasional (5% to 29% of cases)
- HemoglobinuriaHPOHP:0003641
- Occasional (5% to 29% of cases)
- HypertensionHPOHP:0000822
- Occasional (5% to 29% of cases)
- HypokalemiaHPOHP:0002900
- Occasional (5% to 29% of cases)
Where it sits
Other names
7 names
Resolves to: Shiga toxin-associated hemolytic uremic syndrome
- Also called
- D+HUShemolytic-uremic syndrome with diarrheahemolytic-uremic syndrome with diarrhoeaShiga-like toxin-associated HUSSxt-HUStypical hemolytic-uremic syndrometypical HUS