Sheehan syndrome
Findings
No curated finding names Sheehan syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An uncommon cause of hypopituitarism seen after severe postpartum hemorrhaging. Prolonged hypovolemia leads to ischemic necrosis of the pituitary. Clinical signs typically present in the puerperium and include failure to begin lactation, fatigue, hypotension and eventual amenorrhea. Clinical course is usually mild, however extreme cases may progress to adrenal failure. Prognosis is most favorable when hormone replacement is initiated soon after symptom onset.
Definition from the Mondo Disease Ontology (MONDO:0019618), read 2026-09-29. CC BY 4.0.
Features
49 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Adrenocorticotropic hormone deficiencyHPOHP:0011748
- Very frequent (80% to 99% of cases)
- Adrenocorticotropin deficient adrenal insufficiencyHPOHP:0011735
- Very frequent (80% to 99% of cases)
- Chronic fatigueHPOHP:0012432
- Very frequent (80% to 99% of cases)
- Decreased circulating cortisol levelHPOHP:0008163
- Very frequent (80% to 99% of cases)
- OligomenorrheaHPOHP:0000876
- Very frequent (80% to 99% of cases)
- PanhypopituitarismHPOHP:0000871
- Very frequent (80% to 99% of cases)
Show the remaining 37
- Decreased female libidoHPOHP:0030018
- Frequent (30% to 79% of cases)
- Decreased serum estradiolHPOHP:0008214
- Frequent (30% to 79% of cases)
- Dry skinHPOHP:0000958
- Frequent (30% to 79% of cases)
- DyspareuniaHPOHP:0030016
- Frequent (30% to 79% of cases)
- Gonadotropin deficiencyHPOHP:0008213
- Frequent (30% to 79% of cases)
- HeadacheHPOHP:0002315
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: Sheehan syndrome
- Also called
- postpartum hypopituitarismSheehan's syndrome