self-limited epilepsy with centrotemporal spikes
Findings
No curated finding names self-limited epilepsy with centrotemporal spikes yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A childhood-onset epilepsy syndrome that is characterized by onset of seizures between 3 and 14 years (peak 8-9 years) that usually resolve by age 13 years, but can occasionally occur up to age 18 years of age. Both sexes are affected. Antecedent, birth and neonatal history is normal. A history of febrile seizure (in 5-15%) may be seen. A history of Panayiotopoulos syndrome may be present in a very small number of cases. Neurological exam and head size is normal. Development and cognition prior to onset of seizures is normal. During the course of the active epilepsy, behavioral and neuropsychological deficits may be found, particularly in language and executive functioning. These deficits improve when seizures remit.
Definition from the Mondo Disease Ontology (MONDO:0007295), read 2026-09-29. CC BY 4.0.
Features
21 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- EEG with centrotemporal focal spike wavesHPOHP:0012557
- Very frequent (80% to 99% of cases)
- Bilateral tonic-clonic seizure with focal onsetHPOHP:0007334
- Frequent (30% to 79% of cases)
- DroolingHPOHP:0002307
- Frequent (30% to 79% of cases)
- Focal hemifacial clonic seizureHPOHP:0007332
- Frequent (30% to 79% of cases)
- Focal-onset seizureHPOHP:0007359
- Frequent (30% to 79% of cases)
- LaryngospasmHPOHP:0025425
- Frequent (30% to 79% of cases)
- Sleep apnea
Show the remaining 9
- DysesthesiaHPOHP:0012534
- Occasional (5% to 29% of cases)
- Emotional labilityHPOHP:0000712
- Occasional (5% to 29% of cases)
- Febrile seizure (within the age range of 3 months to 6 years)HPOHP:0002373
- Occasional (5% to 29% of cases)
- MigraineHPOHP:0002076
- Occasional (5% to 29% of cases)
- ParesthesiaHPOHP:0003401
- Occasional (5% to 29% of cases)
- Short attention spanHPOHP:0000736
- Occasional (5% to 29% of cases)
Genes
3 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
- Narrower terms (1)
Other names
17 names
Resolves to: self-limited epilepsy with centrotemporal spikes
- Also called
- BCECTSBECRSBECTSbenign childhood epilepsy with centrotemporal spikesbenign epilepsy of childhood with centrotemporal spikesbenign epilepsy with centrotemporal spikesbenign familial epilepsy of childhood with rolandic spikesbenign Rolandic epilepsybenign Rolandic epilepsy (BRE)benign Rolandic epilepsy of childhood (BREC)BREcentralopathic epilepsycentrotemporal epilepsycentrotemporal epilepsy, isolated caseschildhood epilepsy with centrotemporal spikes