selective IgA deficiency disease
Findings
No curated finding names selective IgA deficiency disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class A (IgA). It is the most common primary antibody deficiency. It may be inherited or the reversible sequela of infection or certain drugs. It may be caused by decreased or inefficient class-switching from progenitor B cells without any corresponding decreases in the other isotypes. Though affected persons may be asymptomatic, low levels of IgA will reduce the immune system's ability to combat infection where IgA is normally secreted, at mucosal surfaces. Selective IgA deficiency is seen in greater proportion among patients with autoimmune disorders.
Definition from the Mondo Disease Ontology (MONDO:0001341), read 2026-09-29. CC BY 4.0.
Where it sits
- A kind of
- Narrower terms (3)
Other names
3 names
Resolves to: selective IgA deficiency disease
- Also called
- immunoglobulin A deficiencyselective IgA immunodeficiencySIgAD