scleromyxedema
Findings
No curated finding names scleromyxedema yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Scleromyxedema is a rare, severe skin disorder. Signs and symptoms include abnormal accumulation of mucin in the skin (mucinosis), causing papular and sclerodermoid bumps; increased production of fibroblasts (connective tissue cells) in the absence of a thyroid disorder; and monoclonal gammopathy (abnormal proteins in the blood). It often involves internal organs and may affect various body systems. The cause of scleromyxedema is not known. There is no standard treatment. Management may involve the use of intravenous immunoglobulin (IVIG), plasmapheresis, thalidomide and corticoids, or more aggressive interventions, such as autologous bone marrow transplantation.
Definition from the Mondo Disease Ontology (MONDO:0015665), read 2026-09-29. CC BY 4.0.
Features
40 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Generalized abnormality of skinHPOHP:0011354
- Very frequent (80% to 99% of cases)
- PapuleHPOHP:0200034
- Very frequent (80% to 99% of cases)
- ParaproteinemiaHPOHP:0031047
- Very frequent (80% to 99% of cases)
- Abnormal forearm morphologyHPOHP:0002973
- Frequent (30% to 79% of cases)
- Abnormality of the faceHPOHP:0000271
- Frequent (30% to 79% of cases)
- Abnormality of the glabellaHPOHP:0002056
- Frequent (30% to 79% of cases)
- Abnormality of the hand
Show the remaining 28
- Proximal muscle weaknessHPOHP:0003701
- Frequent (30% to 79% of cases)
- SclerodactylyHPOHP:0011838
- Frequent (30% to 79% of cases)
- Skin-colored papuleHPOHP:0025512
- Frequent (30% to 79% of cases)
- Stiff skinHPOHP:0030053
- Frequent (30% to 79% of cases)
- Thickened skinHPOHP:0001072
- Frequent (30% to 79% of cases)
- Abnormal lung morphologyHPOHP:0002088
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
6 names
Resolves to: scleromyxedema
- Also called
- Arndt-Gottron diseasegeneralised lichenoid papular eruptiongeneralised papular and sclerodermoid lichen myxedematosusgeneralized lichenoid papular eruptiongeneralized papular and sclerodermoid lichen myxedematosusscleromyxoedema