schisis association
MONDO:0018976Mondo
Findings
No curated finding names schisis association yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
The combination of two or more of the following anomalies: neural tube defects (e.g. anencephaly, encephalocele, spina bifida cystica), cleft lip/palate, omphalocele and congenital diaphragmatic hernia. These anomalies are associated at a higher frequency than would be expected with random combination rates.
Definition from the Mondo Disease Ontology (MONDO:0018976), read 2026-09-29. CC BY 4.0.
Features
15 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AnencephalyHPOHP:0002323
- Very frequent (80% to 99% of cases)
- Cleft palateHPOHP:0000175
- Very frequent (80% to 99% of cases)
- OmphaloceleHPOHP:0001539
- Very frequent (80% to 99% of cases)
- Premature birthHPOHP:0001622
- Very frequent (80% to 99% of cases)
- Small for gestational ageHPOHP:0001518
- Very frequent (80% to 99% of cases)
- Unilateral cleft lipHPOHP:0100333
- Very frequent (80% to 99% of cases)
- Congenital diaphragmatic herniaHPOHP:0000776
- Frequent (30% to 79% of cases)
- EncephaloceleHPOHP:0002084
- Frequent (30% to 79% of cases)
- Spina bifidaHPOHP:0002414
- Frequent (30% to 79% of cases)
- Abnormal cardiovascular system morphologyHPOHP:0030680
- Occasional (5% to 29% of cases)
- Anal atresiaHPOHP:0002023
- Occasional (5% to 29% of cases)
- MicrocephalyHPOHP:0000252
- Occasional (5% to 29% of cases)
Show the remaining 3
- MicromeliaHPOHP:0002983
- Occasional (5% to 29% of cases)
- Renal agenesisHPOHP:0000104
- Occasional (5% to 29% of cases)
- Tracheoesophageal fistulaHPOHP:0002575
- Occasional (5% to 29% of cases)
Where it sits
- A kind of