Schilder disease
MONDO:0010085Mondo
Findings
No curated finding names Schilder disease yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Schilder's disease is a progressive demyelinating disorder of the central nervous system.
Definition from the Mondo Disease Ontology (MONDO:0010085), read 2026-09-29. CC BY 4.0.
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- CNS demyelinationHPOHP:0007305
- Frequent (30% to 79% of cases)
- HeadacheHPOHP:0002315
- Frequent (30% to 79% of cases)
- Hyperintensity of cerebral white matter on MRIHPOHP:0030890
- Frequent (30% to 79% of cases)
- HyperreflexiaHPOHP:0001347
- Frequent (30% to 79% of cases)
- Increased CSF protein concentrationHPOHP:0002922
- Frequent (30% to 79% of cases)
- Progressive neurologic deteriorationHPOHP:0002344
- Frequent (30% to 79% of cases)
- Ankle clonusHPOHP:0011448
- Occasional (5% to 29% of cases)
- AtaxiaHPOHP:0001251
- Occasional (5% to 29% of cases)
- CSF pleocytosisHPOHP:0012229
- Occasional (5% to 29% of cases)
- DiplopiaHPOHP:0000651
- Occasional (5% to 29% of cases)
- EncephalopathyHPOHP:0001298
- Occasional (5% to 29% of cases)
- EsotropiaHPOHP:0000565
- Occasional (5% to 29% of cases)
Show the remaining 7
- Increased intracranial pressureHPOHP:0002516
- Occasional (5% to 29% of cases)
- Muscle weaknessHPOHP:0001324
- Occasional (5% to 29% of cases)
- NauseaHPOHP:0002018
- Occasional (5% to 29% of cases)
- Postural instabilityHPOHP:0002172
- Occasional (5% to 29% of cases)
- SeizureHPOHP:0001250
- Occasional (5% to 29% of cases)
- VertigoHPOHP:0002321
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: Schilder disease
- Also called
- myelinoclastic diffuse sclerosisSchilder's disease