SAPHO syndrome
MONDO:0019266Mondo
Findings
No curated finding names SAPHO syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
SAPHO syndrome (acronym for Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is an auto-inflammatory disease, mainly characterized by the association of neutrophilic cutaneous involvement and chronic osteomyelitis.
Definition from the Mondo Disease Ontology (MONDO:0019266), read 2026-09-29. CC BY 4.0.
Features
30 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal thorax morphologyHPOHP:0000765
- Very frequent (80% to 99% of cases)
- ArthralgiaHPOHP:0002829
- Very frequent (80% to 99% of cases)
- Bone painHPOHP:0002653
- Very frequent (80% to 99% of cases)
- Chest painHPOHP:0100749
- Very frequent (80% to 99% of cases)
- Craniofacial osteosclerosisHPOHP:0005464
- Very frequent (80% to 99% of cases)
- EnthesitisHPOHP:0100686
- Very frequent (80% to 99% of cases)
- HyperostosisHPOHP:0100774
- Very frequent (80% to 99% of cases)
- Neoplasm of the skeletal systemHPOHP:0010622
- Very frequent (80% to 99% of cases)
- OsteolysisHPOHP:0002797
- Very frequent (80% to 99% of cases)
- PustuleHPOHP:0200039
- Very frequent (80% to 99% of cases)
- SynovitisHPOHP:0100769
- Very frequent (80% to 99% of cases)
- Abnormal sacroiliac joint morphologyHPOHP:0100781
- Frequent (30% to 79% of cases)
Show the remaining 18
- Abnormality of the vertebral columnHPOHP:0000925
- Frequent (30% to 79% of cases)
- AcneHPOHP:0001061
- Frequent (30% to 79% of cases)
- ArthritisHPOHP:0001369
- Frequent (30% to 79% of cases)
- EdemaHPOHP:0000969
- Frequent (30% to 79% of cases)
- OsteomyelitisHPOHP:0002754
- Frequent (30% to 79% of cases)
- Palmoplantar pustulosisHPOHP:0100847
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
4 names
Resolves to: SAPHO syndrome
- Also called
- PPHSPustulo-psoriatic hyperostotic Spondyloarthritissynovitis-acne-pustulosis-hyperostosis-osteitis syndromesynovitis, acne, pustulosis, hyperostosis, and osteitis syndrome