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A reference for what the literature reports. Not medical advice.

Disease

Richter transformation

MONDO:0002083Mondo

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Findings

No curated finding names Richter transformation yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.

Definition

Transformation of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) into a more aggressive type of lymphoma, usually diffuse large B-cell lymphoma (immunoblastic or centroblastic variant). Occasional cases of transformation to Hodgkin's lymphoma have also been described, particularly in patients treated with purine nucleotide analogs. Molecular genetic studies suggest that in approximately half of the cases, the lymphoma is clonally related to the underlying CLL/SLL, whereas in the remaining cases the lymphoma probably represents a secondary, unrelated neoplasm.

Definition from the Mondo Disease Ontology (MONDO:0002083), read 2026-09-29. CC BY 4.0.

Where it sits

A kind of: secondary neoplasm

Other names

5 names

Resolves to: Richter transformation

Also called: chronic lymphocytic leukemia with Richter transformationchronic lymphocytic leukemia/small lymphocytic lymphoma with Richter transformationRichter syndromeRichter's syndromeRichter's transformation