Reynolds syndrome
MONDO:0013276Mondo
Findings
No curated finding names Reynolds syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An autoimmune disorder characterized by the association of primary biliary cirrhosis (PBC) with limited cutaneous systemic sclerosis (lcSSc).
Definition from the Mondo Disease Ontology (MONDO:0013276), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Late young adult onset
HPO, annotations 2026-09-02
Features
35 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Anti-centromere antibody positivityHPOHP:0030873
- 1 of 1 reported patient
- Antimitochondrial antibody positivityHPOHP:0030167
- 1 of 1 reported patient
- Antinuclear antibody positivityHPOHP:0003493
- 1 of 1 reported patient
- ArthralgiaHPOHP:0002829
- 1 of 1 reported patient
- AstheniaHPOHP:0025406
- 1 of 1 reported patient
- CholestasisHPOHP:0001396
- 1 of 1 reported patient
- Decreased total lymphocyte countHPOHP:0001888
Show the remaining 23
- FatigueHPOHP:0012378
- Very frequent (80% to 99% of cases)
- Gastroesophageal refluxHPOHP:0002020
- Very frequent (80% to 99% of cases)
- Generalized abnormality of skinHPOHP:0011354
- Very frequent (80% to 99% of cases)
- HepatomegalyHPOHP:0002240
- Very frequent (80% to 99% of cases)
- MyalgiaHPOHP:0003326
- Very frequent (80% to 99% of cases)
- PruritusHPOHP:0000989
- Very frequent (80% to 99% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: Reynolds syndrome
- Also called
- primary biliary cirrhosis and systemic scleroderma