pyogenic bacterial infections due to MyD88 deficiency
Findings
No curated finding names pyogenic bacterial infections due to MyD88 deficiency yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Pyogenic bacterial infection due to MyD88 deficiency is a primary immunodeficiency characterized by increased susceptibility to pyogenic bacterial infections, including invasive pneumococcal, invasive staphylococcal and pseudomonas disease.
Definition from the Mondo Disease Ontology (MONDO:0012839), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal recessive inheritance
HPO, annotations 2026-09-02
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Delayed umbilical cord separationHPOHP:0032434
- 1 of 1 reported patient · Congenital onset
- Recurrent meningitisHPOHP:0006946
- 5 of 9 reported patients
- AbscessHPOHP:0025615
- 4 of 9 reported patients
- Recurrent skin infectionsHPOHP:0001581
- 2 of 9 reported patients
- Decreased total B cell countHPOHP:0010976
- 1 of 8 reported patients
- SepsisHPOHP:0100806
- 1 of 9 reported patients
- Septic arthritisHPO
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- MYD88HGNC:7562
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal recessive · 2019
- Strong · PanelApp Australia · Autosomal recessive · 2025
- Moderate · Ambry Genetics · Autosomal recessive · 2018
Where it sits
- A kind of
Other names
5 names
Resolves to: pyogenic bacterial infections due to MyD88 deficiency
- Also called
- immunodeficiency 68MyD88 deficiencyMYD88Dpyogenic bacterial infections, recurrent, due to MyD88 deficiencyrecurrent pyogenic bacterial infections due to MyD88 deficiency