pure autonomic failure
MONDO:0018608Mondo
Findings
No curated finding names pure autonomic failure yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension.
Definition from the Mondo Disease Ontology (MONDO:0018608), read 2026-09-29. CC BY 4.0.
Features
10 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal autonomic nervous system physiologyHPOHP:0012332
- Very frequent (80% to 99% of cases)
- Abnormal circulating catecholamine concentrationHPOHP:0012099
- Very frequent (80% to 99% of cases)
- AnhidrosisHPOHP:0000970
- Very frequent (80% to 99% of cases)
- Constitutional symptomHPOHP:0025142
- Very frequent (80% to 99% of cases)
- Orthostatic hypotensionHPOHP:0001278
- Very frequent (80% to 99% of cases)
- ConstipationHPOHP:0002019
- Frequent (30% to 79% of cases)
- DysuriaHPOHP:0100518
- Frequent (30% to 79% of cases)
- SyncopeHPOHP:0001279
- Frequent (30% to 79% of cases)
- Urinary incontinenceHPOHP:0000020
- Frequent (30% to 79% of cases)
- ImpotenceHPOHP:0000802
- Occasional (5% to 29% of cases)
Where it sits
Other names
6 names
Resolves to: pure autonomic failure
- Also called
- Bradbury Eggleston syndromeBradbury-Eggleston syndromeidiopathic orthostatic hypotensionPAFPure dysautonomiaPure idiopatic dysautonomia