progressive non-fluent aphasia
MONDO:0015059Mondo
Findings
No curated finding names progressive non-fluent aphasia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Progressive non-fluent aphasia (PNFA) is a form of frontotemporal dementia (FTD), characterized by agrammatism, laborious speech, alexia, and agraphia, frequently accompanied by apraxia of speech (AOS). Language comprehension is relatively preserved.
Definition from the Mondo Disease Ontology (MONDO:0015059), read 2026-09-29. CC BY 4.0.
Features
28 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AphasiaHPOHP:0002381
- Very frequent (80% to 99% of cases)
- Deficit in grammarHPOHP:0006977
- Very frequent (80% to 99% of cases)
- Frontotemporal cerebral atrophyHPOHP:0006892
- Very frequent (80% to 99% of cases)
- Frontotemporal dementiaHPOHP:0002145
- Very frequent (80% to 99% of cases)
- Memory impairmentHPOHP:0002354
- Very frequent (80% to 99% of cases)
- Mental deteriorationHPOHP:0001268
- Very frequent (80% to 99% of cases)
- Spoken word recognition deficitHPOHP:0030391
- Very frequent (80% to 99% of cases)
- Temporal cortical atrophyHPOHP:0007112
- Very frequent (80% to 99% of cases)
- Thickened nuchal skin foldHPOHP:0000474
- Very frequent (80% to 99% of cases)
- Abnormal brain FDG positron emission tomographyHPOHP:0012658
- Frequent (30% to 79% of cases)
- Abnormal cerebral white matter morphologyHPOHP:0002500
- Frequent (30% to 79% of cases)
- AlexiaHPOHP:0010523
- Frequent (30% to 79% of cases)
Reported absent (4)
- Brain neoplasmHPOHP:0030692
- Lewy bodiesHPOHP:0100315
- Neurofibrillary tanglesHPOHP:0002185
- StrokeHPOHP:0001297
Show the remaining 16
- AnxietyHPOHP:0000739
- Frequent (30% to 79% of cases)
- ApraxiaHPOHP:0002186
- Frequent (30% to 79% of cases)
- DepressionHPOHP:0000716
- Frequent (30% to 79% of cases)
- EEG with continuous slow activityHPOHP:0011204
- Frequent (30% to 79% of cases)
- Abnormal lower motor neuron morphologyHPOHP:0002366
- Occasional (5% to 29% of cases)
- Abnormality of extrapyramidal motor functionHPOHP:0002071
- Occasional (5% to 29% of cases)
Where it sits
- Narrower terms (1)
Other names
4 names
Resolves to: progressive non-fluent aphasia
- Also called
- Agramatic variant of PPAAgramatic variant of primary progressive aphasianon-fluent variant PPAPrimary Progressive Nonfluent aphasia