progressive multifocal leukoencephalopathy
Findings
No curated finding names progressive multifocal leukoencephalopathy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but itrarelycauses symptoms unless the immune system becomes severely weakened.The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as Hodgkins disease, lymphoma, and sarcoidosis. PML is most common among individuals with acquired immune deficiency syndrome (AIDS).
Definition from the Mondo Disease Ontology (MONDO:0016318), read 2026-09-29. CC BY 4.0.
Features
35 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal astrocyte morphologyHPOHP:0100707
- Very frequent (80% to 99% of cases)
- Abnormal CD4+ T cell subset proportionHPOHP:0031392
- Very frequent (80% to 99% of cases)
- Abnormal cerebrospinal fluid morphologyHPOHP:0002921
- Very frequent (80% to 99% of cases)
- Abnormal oligodendroglia morphologyHPOHP:0100706
- Very frequent (80% to 99% of cases)
- Abnormality of the nervous systemHPOHP:0000707
- Very frequent (80% to 99% of cases)
- CNS demyelinationHPOHP:0007305
- Very frequent (80% to 99% of cases)
Show the remaining 23
- Gait ataxiaHPOHP:0002066
- Frequent (30% to 79% of cases)
- HeadacheHPOHP:0002315
- Frequent (30% to 79% of cases)
- Hemiplegia/hemiparesisHPOHP:0004374
- Frequent (30% to 79% of cases)
- Limb muscle weaknessHPOHP:0003690
- Frequent (30% to 79% of cases)
- Mental deteriorationHPOHP:0001268
- Frequent (30% to 79% of cases)
- Somatic sensory dysfunctionHPOHP:0003474
- Frequent (30% to 79% of cases)
Where it sits
- A kind of
Other names
2 names
Resolves to: progressive multifocal leukoencephalopathy
- Also called
- PMLprogressive multifocal leukoencephalitis