primary unilateral adrenal hyperplasia
Findings
No curated finding names primary unilateral adrenal hyperplasia yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Primary unilateral adrenal hyperplasia (PUAH) is a surgically-correctable form of primary (hyper) aldosteronism (PA) characterized by renin suppression, unilateral aldosterone hypersecretion, and moderate to severe hypertension secondary to hyperplasia of the adrenal gland.
Definition from the Mondo Disease Ontology (MONDO:0016504), read 2026-09-29. CC BY 4.0.
Features
15 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Decreased circulating renin concentrationHPOHP:0003351
- Obligate (100% of cases)
- Glucocortocoid-insensitive primary hyperaldosteronismHPOHP:0011740
- Obligate (100% of cases)
- HypertensionHPOHP:0000822
- Obligate (100% of cases)
- Adrenal hyperplasiaHPOHP:0008221
- Frequent (30% to 79% of cases)
- HypokalemiaHPOHP:0002900
- Frequent (30% to 79% of cases)
- Increased urinary potassiumHPOHP:0003081
- Frequent (30% to 79% of cases)
- Metabolic alkalosisHPOHP:0200114
- Frequent (30% to 79% of cases)
- EpistaxisHPOHP:0000421
- Occasional (5% to 29% of cases)
- HeadacheHPOHP:0002315
- Occasional (5% to 29% of cases)
- Muscle spasmHPOHP:0003394
- Occasional (5% to 29% of cases)
- Muscle weaknessHPOHP:0001324
- Occasional (5% to 29% of cases)
- NauseaHPOHP:0002018
- Occasional (5% to 29% of cases)
Show the remaining 3
- PalpitationsHPOHP:0001962
- Occasional (5% to 29% of cases)
- PolydipsiaHPOHP:0001959
- Occasional (5% to 29% of cases)
- TinnitusHPOHP:0000360
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: primary unilateral adrenal hyperplasia
- Also called
- PUAH