primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection
Findings
No curated finding names primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection is a rare primary immunodeficiency due to a defect in innate immunity disorder characterized by selective susceptibility to viral infections, particularly after systemic challenge with live viral vaccines, such as the measles, mumps and rubella (MMR) vaccine. Patients present severe, potentially fatal, manifestations to viral illness, including encephalitis, hepatitis and pneumonitis.
Definition from the Mondo Disease Ontology (MONDO:0014715), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal recessive inheritance
- Onset and course
- Infantile onset · Childhood onset
HPO, annotations 2026-09-02
Features
9 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Decreased circulating IgA concentrationHPOHP:0002720
- 2 of 2 reported patients
- Decreased total lymphocyte countHPOHP:0001888
- 2 of 2 reported patients
- Elevated CSF neopterin levelHPOHP:0040204
- 2 of 2 reported patients
- Severe viral infectionHPOHP:0031691
- 3 of 5 reported patients
- Decreased circulating IgM concentrationHPOHP:0002850
- 1 of 2 reported patients
- Elevated circulating alanine aminotransferase concentration
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- STAT2HGNC:11363
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal recessive · 2023
- Strong · PanelApp Australia · Autosomal recessive · 2025
- Supportive · Orphanet · Autosomal recessive · 2021
- Limited · G2P · Autosomal recessive · 2015
Where it sits
Other names
4 names
Resolves to: primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection
- Also called
- IMD44immunodeficiency 44immunodeficiency type 44primary immunodeficiency with post-MMR vaccine viral infection