premature ovarian failure 21
MONDO:0957216Mondo
Findings
No curated finding names premature ovarian failure 21 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
- Inheritance
- Autosomal dominant inheritance
- Onset and course
- Young adult onset
HPO, annotations 2026-09-02
Features
6 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Decreased serum estradiolHPOHP:0008214
- 11 of 11 reported patients · Female
- Elevated circulating follicle stimulating hormone levelHPOHP:0008232
- 11 of 11 reported patients · Female
- Streak ovaryHPOHP:0010464
- 3 of 4 reported patients · Female
- Secondary amenorrheaHPOHP:0000869
- 10 of 15 reported patients · Female
- Primary amenorrheaHPOHP:0000786
- 7 of 17 reported patients · Female
- Precocious puberty in femalesHPOHP:0010465
- 1 of 4 reported patients · Female
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- TP63HGNC:15979
- Strong · Labcorp Genetics (formerly Invitae) · Autosomal dominant · 2023
- Moderate · Ambry Genetics · Autosomal dominant · 2025
Where it sits
- A kind of