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A reference for what the literature reports. Not medical advice.

Disease

pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma

MONDO:0004478Mondo

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Findings

No curated finding names pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.

Definition

A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that lacks somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes, implying pregerminal center B-cell origin. Microarray gene expression profiling studies have demonstrated the expression of ZAP-70 gene (Syk family tyrosine kinase) in this subset of CLL/CLL. Patients with this variant of CLL/SLL have an unfavorable prognosis compared to those with somatic hypermutations of the IGH genes, with a median survival of approximately 6-8 years.

Definition from the Mondo Disease Ontology (MONDO:0004478), read 2026-09-29. CC BY 4.0.

Where it sits

A kind of: chronic lymphocytic leukemia/small lymphocytic lymphoma

Other names

2 names

Resolves to: pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma

Also called: chronic lymphocytic leukemia/small lymphocytic lymphoma with unmutated Immunoglobulin heavy chain variable-region GeneCLL/SLL with unmutated IGVH