PPoma
Findings
No curated finding names PPoma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
PPoma is a type of pancreatic endocrine tumor that hypersecretes pancreatic polypeptide (PP) but that does not cause a hypersecretion syndrome (is non-functioning) and instead presents with only non-specific symptoms such as weight loss, abdominal pain, jaundice, diarrhea and/or an abdominal mass, hence leading to a late diagnosis. PPoma can be associated with multiple endocrine neoplasia 1 (MEN-1).
Definition from the Mondo Disease Ontology (MONDO:0019957), read 2026-09-29. CC BY 4.0.
Features
32 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Neoplasm of the pancreasHPOHP:0002894
- Very frequent (80% to 99% of cases)
- Neoplasm of the small intestineHPOHP:0100833
- Very frequent (80% to 99% of cases)
- Abnormal abdomen morphologyHPOHP:0001438
- Frequent (30% to 79% of cases)
- AnorexiaHPOHP:0002039
- Frequent (30% to 79% of cases)
- ConstipationHPOHP:0002019
- Frequent (30% to 79% of cases)
- DiarrheaHPOHP:0002014
- Frequent (30% to 79% of cases)
- Episodic abdominal painHPOHP:0002574
- Frequent (30% to 79% of cases)
- HepatomegalyHPOHP:0002240
- Frequent (30% to 79% of cases)
- Hypoactive bowel soundsHPOHP:0030144
- Frequent (30% to 79% of cases)
- Nausea and vomitingHPOHP:0002017
- Frequent (30% to 79% of cases)
- Poor appetiteHPOHP:0004396
- Frequent (30% to 79% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
Show the remaining 20
- AscitesHPOHP:0001541
- Occasional (5% to 29% of cases)
- CholelithiasisHPOHP:0001081
- Occasional (5% to 29% of cases)
- Extrahepatic cholestasisHPOHP:0012334
- Occasional (5% to 29% of cases)
- Gastrointestinal hemorrhageHPOHP:0002239
- Occasional (5% to 29% of cases)
- Intermittent jaundiceHPOHP:0001046
- Occasional (5% to 29% of cases)
- Intestinal carcinoidHPOHP:0006723
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
4 names
Resolves to: PPoma
- Also called
- pancreatic polypeptide neoplasmpancreatic polypeptide tumorpancreatic polypeptide tumourpancreatic polypeptidoma