polyarteritis nodosa
Findings
No curated finding names polyarteritis nodosa yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Polyarteritis nodosa (PAN) is a rare, clinically heterogeneous, rheumatologic disease characterized by necrotizing inflammatory lesions affecting small- and medium-sized blood vessels. PAN most commonly affects skin, joints, peripheral nerves, the gut, and the kidney.
Definition from the Mondo Disease Ontology (MONDO:0019170), read 2026-09-29. CC BY 4.0.
Features
28 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal skin morphologyHPOHP:0011121
- Very frequent (80% to 99% of cases)
- Abnormality of the kidneyHPOHP:0000077
- Frequent (30% to 79% of cases)
- ArthralgiaHPOHP:0002829
- Frequent (30% to 79% of cases)
- Elevated circulating C-reactive protein concentrationHPOHP:0011227
- Frequent (30% to 79% of cases)
- FeverHPOHP:0001945
- Frequent (30% to 79% of cases)
- Livedo racemosaHPOHP:0033260
- Frequent (30% to 79% of cases)
- MyalgiaHPOHP:0003326
- Frequent (30% to 79% of cases)
- Peripheral neuropathyHPOHP:0009830
- Frequent (30% to 79% of cases)
- Polyarticular arthritisHPOHP:0005764
- Frequent (30% to 79% of cases)
- PolyneuritisHPOHP:0031003
- Frequent (30% to 79% of cases)
- Weight lossHPOHP:0001824
- Frequent (30% to 79% of cases)
- Abdominal painHPOHP:0002027
- Occasional (5% to 29% of cases)
Show the remaining 16
- Abnormal cardiovascular system morphologyHPOHP:0030680
- Occasional (5% to 29% of cases)
- Abnormal lung morphologyHPOHP:0002088
- Occasional (5% to 29% of cases)
- Abnormality of the gastrointestinal tractHPOHP:0011024
- Occasional (5% to 29% of cases)
- Abnormality of the nervous systemHPOHP:0000707
- Occasional (5% to 29% of cases)
- Cutis marmorataHPOHP:0000965
- Occasional (5% to 29% of cases)
- ErythemaHPOHP:0010783
- Occasional (5% to 29% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- ADA2HGNC:1839
- Moderate · Genomics England PanelApp · Autosomal recessive · 2021
Where it sits
- A kind of
- Narrower terms (2)
Other names
6 names
Resolves to: polyarteritis nodosa
- Also called
- classic polyarteritis nodosaclassical polyarteritis nodosaKüssmaul-Maier diseasePANpanarteritis nodosaperiarteritis nodosa