POEMS syndrome
Findings
No curated finding names POEMS syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.
Definition from the Mondo Disease Ontology (MONDO:0017364), read 2026-09-29. CC BY 4.0.
Features
51 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- PolyneuropathyHPOHP:0001271
- Obligate (100% of cases)
- Abnormal skin physiologyHPOHP:0011122
- Very frequent (80% to 99% of cases)
- Abnormality of the endocrine systemHPOHP:0000818
- Very frequent (80% to 99% of cases)
- HypogonadismHPOHP:0000135
- Very frequent (80% to 99% of cases)
- Increased circulating immunoglobulin concentrationHPOHP:0010702
- Very frequent (80% to 99% of cases)
- Lymphoproliferative disorderHPOHP:0005523
- Very frequent (80% to 99% of cases)
- VisceromegalyHPOHP:0003271
- Very frequent (80% to 99% of cases)
- AreflexiaHPOHP:0001284
- Frequent (30% to 79% of cases)
- AscitesHPOHP:0001541
- Frequent (30% to 79% of cases)
- Clubbing of fingersHPOHP:0100759
- Frequent (30% to 79% of cases)
- Diabetes mellitusHPOHP:0000819
- Frequent (30% to 79% of cases)
- EdemaHPOHP:0000969
- Frequent (30% to 79% of cases)
Show the remaining 39
- Elevated vascular endothelial growth factor levelHPOHP:0031052
- Frequent (30% to 79% of cases)
- Erectile dysfunctionHPOHP:0100639
- Frequent (30% to 79% of cases)
- FatigueHPOHP:0012378
- Frequent (30% to 79% of cases)
- GynecomastiaHPOHP:0000771
- Frequent (30% to 79% of cases)
- HemangiomaHPOHP:0001028
- Frequent (30% to 79% of cases)
- HepatomegalyHPOHP:0002240
- Frequent (30% to 79% of cases)
Where it sits
Other names
5 names
Resolves to: POEMS syndrome
- Also called
- Crow-Fukase syndromeosteosclerotic myelomaPEP syndromepolyneuropathy-endocrinopathy-plasma cell dyscrasia syndromeTakatsuki syndrome