plasma cell myeloma
Findings
No curated finding names plasma cell myeloma yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)
Definition from the Mondo Disease Ontology (MONDO:0009693), read 2026-09-29. CC BY 4.0.
- Onset and course
- Adult onset
HPO, annotations 2026-09-02
Features
31 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- OsteopeniaHPOHP:0000938
- Very frequent (80% to 99% of cases)
- Pathologic fractureHPOHP:0002756
- Very frequent (80% to 99% of cases)
- Acute kidney injuryHPOHP:0001919
- Frequent (30% to 79% of cases)
- AnemiaHPOHP:0001903
- Frequent (30% to 79% of cases)
- Bone painHPOHP:0002653
- Frequent (30% to 79% of cases)
- Decreased circulating immunoglobulin concentrationHPOHP:0004313
- Frequent (30% to 79% of cases)
- Elevated circulating creatinine concentration
Show the remaining 19
- Nephrotic syndromeHPOHP:0000100
- Frequent (30% to 79% of cases)
- OsteolysisHPOHP:0002797
- Frequent (30% to 79% of cases)
- PallorHPOHP:0000980
- Frequent (30% to 79% of cases)
- Abnormal vitamin B12 concentrationHPOHP:0004341
- Occasional (5% to 29% of cases)
- Abnormality of the bladderHPOHP:0000014
- Occasional (5% to 29% of cases)
- Constrictive median neuropathyHPOHP:0012185
- Occasional (5% to 29% of cases)
Where it sits
Other names
13 names
Resolves to: plasma cell myeloma
- Also called
- Kahler diseaseKahler's diseasemedullary plasmacytomaMultiple Myelomamultiple myeloma, resistance to, Somatic mutationmultiple myeloma, susceptibility to, Somatic mutationmultiple myeloma/plasma cell myelomamyeloid neoplasm of plasma cellmyelomamyeloma, multiplemyeloma, plasma cell, malignantmyelomatosisplasma cell myeloid neoplasm