pituitary gigantism
Findings
No curated finding names pituitary gigantism yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
The condition of accelerated and excessive growth in children or adolescents who are exposed to excess human growth hormone before the closure of epiphyses. It is usually caused by somatotroph hyperplasia or a growth hormone-secreting pituitary adenoma. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
Definition from the Mondo Disease Ontology (MONDO:0020479), read 2026-09-29. CC BY 4.0.
Features
20 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Accelerated skeletal maturationHPOHP:0005616
- Very frequent (80% to 99% of cases)
- Coarse facial featuresHPOHP:0000280
- Very frequent (80% to 99% of cases)
- Elevated circulating growth hormone concentrationHPOHP:0000845
- Very frequent (80% to 99% of cases)
- Frontal bossingHPOHP:0002007
- Very frequent (80% to 99% of cases)
- HyperhidrosisHPOHP:0000975
- Very frequent (80% to 99% of cases)
- Hypertrophic cardiomyopathyHPOHP:0001639
- Very frequent (80% to 99% of cases)
- Increased circulating insulin-like growth factor 1 concentrationHPOHP:0030269
- Very frequent (80% to 99% of cases)
- Large handsHPOHP:0001176
- Very frequent (80% to 99% of cases)
- Left ventricular hypertrophyHPOHP:0001712
- Very frequent (80% to 99% of cases)
- Long footHPOHP:0001833
- Very frequent (80% to 99% of cases)
- Mandibular prognathiaHPOHP:0000303
- Very frequent (80% to 99% of cases)
- Pituitary growth hormone cell adenomaHPOHP:0011760
- Very frequent (80% to 99% of cases)
Show the remaining 8
- Premature pubarcheHPOHP:0012411
- Very frequent (80% to 99% of cases)
- Proportionate tall statureHPOHP:0011407
- Very frequent (80% to 99% of cases)
- Tall statureHPOHP:0000098
- Very frequent (80% to 99% of cases)
- Type II diabetes mellitusHPOHP:0005978
- Very frequent (80% to 99% of cases)
- AmenorrheaHPOHP:0000141
- Frequent (30% to 79% of cases)
- Increased circulating prolactin concentrationHPOHP:0000870
- Frequent (30% to 79% of cases)
Genes
2 genes
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
Where it sits
Other names
2 names
Resolves to: pituitary gigantism
- Also called
- hypophyseal gigantisminfantile and juvenile forms of acromegaly