persistent placoid maculopathy
Findings
No curated finding names persistent placoid maculopathy yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Persistent placoid maculopathy is characterized by white plaque-like lesions involving the macula but sparing the peripapillary areas of both eyes. It has been described in five patients. In contrast to patients with macular serpiginous choroiditis presenting with similar lesions, the five patients reported so far with persistent placoid maculopathy had good visual acuity until the onset of choroidal neovascularization (CNV) or pigmentary mottling. The macular lesions fade after several months or years, but the vascular anomalies persist leading to a loss of central vision.
Definition from the Mondo Disease Ontology (MONDO:0019973), read 2026-09-29. CC BY 4.0.
Features
8 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Choroidal neovascularizationHPOHP:0011506
- Obligate (100% of cases)
- Reduced visual acuityHPOHP:0007663
- Obligate (100% of cases)
- Abnormal macular morphologyHPOHP:0001103
- Very frequent (80% to 99% of cases)
- AmblyopiaHPOHP:0000646
- Occasional (5% to 29% of cases)
- Hypoplasia of the foveaHPOHP:0007750
- Occasional (5% to 29% of cases)
- MetamorphopsiaHPOHP:0012508
- Occasional (5% to 29% of cases)
- Retinal pigment epithelial mottling
Where it sits
- A kind of