paroxysmal cold hemoglobinuria
MONDO:0019533Mondo
Findings
No curated finding names paroxysmal cold hemoglobinuria yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Paroxysmal cold hemoglobinuria (PCH) is a very rare subtype of autoimmune hemolytic anemia (AIHA), caused by the presence of cold-reacting autoantibodies in the blood and characterized by the sudden presence of hemoglobinuria, typically after exposure to cold temperatures.
Definition from the Mondo Disease Ontology (MONDO:0019533), read 2026-09-29. CC BY 4.0.
Features
11 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal urinary colorHPOHP:0012086
- Very frequent (80% to 99% of cases)
- ArthralgiaHPOHP:0002829
- Very frequent (80% to 99% of cases)
- Autoimmune hemolytic anemiaHPOHP:0001890
- Very frequent (80% to 99% of cases)
- Back painHPOHP:0003418
- Very frequent (80% to 99% of cases)
- Coombs-positive hemolytic anemiaHPOHP:0004844
- Very frequent (80% to 99% of cases)
- FeverHPOHP:0001945
- Very frequent (80% to 99% of cases)
- HeadacheHPOHP:0002315
- Very frequent (80% to 99% of cases)
- HemoglobinuriaHPOHP:0003641
- Very frequent (80% to 99% of cases)
- Recurrent respiratory infectionsHPOHP:0002205
- Very frequent (80% to 99% of cases)
- DiarrheaHPOHP:0002014
- Occasional (5% to 29% of cases)
- Nausea and vomitingHPOHP:0002017
- Occasional (5% to 29% of cases)
Where it sits
Other names
4 names
Resolves to: paroxysmal cold hemoglobinuria
- Also called
- Donath-Landsteiner hemolytic anaemiaDonath-Landsteiner hemolytic anemiaDonath-Landsteiner syndromePCH