Parkinson disease 11, autosomal dominant, susceptibility to
Findings
No curated finding names Parkinson disease 11, autosomal dominant, susceptibility to yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
An inherited susceptibility or predisposition to developing late onset Parkinson disease, in which the cause of the disease is a mutation in the GIGYF2 gene.
Definition from the Mondo Disease Ontology (MONDO:0011896), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
HPO, annotations 2026-09-02
Features
5 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- BradykinesiaHPOHP:0002067
- Parkinsonism with favorable response to dopaminergic medicationHPOHP:0002548
- Postural instabilityHPOHP:0002172
- Resting tremorHPOHP:0002322
- RigidityHPOHP:0002063
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- GIGYF2HGNC:11960
- Moderate · Genomics England PanelApp · Autosomal dominant · 2021
- Limited · Ambry Genetics · Autosomal dominant · 2018
- Limited · Labcorp Genetics (formerly Invitae) · Unknown · 2022
- Limited · PanelApp Australia · Autosomal dominant · 2025
Where it sits
- A kind of
Other names
3 names
Resolves to: Parkinson disease 11, autosomal dominant, susceptibility to
- Also called
- GIGYF2 hereditary late onset Parkinson diseasehereditary late onset Parkinson disease caused by mutation in GIGYF2Parkinson disease 11