parenteral nutrition-associated cholestasis
Findings
No curated finding names parenteral nutrition-associated cholestasis yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare hepatic disease characterized by intrahepatic cholestasis and deterioration of liver function in patients receiving parenteral nutrition for extended periods of time (signs may appear as early as within the first two weeks of initiation of parenteral nutrition). The condition commonly occurs in neonates and usually resolves with transition to enteral feeding, although severe cases may progress to liver fibrosis, cirrhosis, and portal hypertension.
Definition from the Mondo Disease Ontology (MONDO:0035777), read 2026-09-29. CC BY 4.0.
Features
22 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abdominal painHPOHP:0002027
- Frequent (30% to 79% of cases)
- Abnormal circulating fatty acid concentrationHPOHP:0004359
- Frequent (30% to 79% of cases)
- Abnormal metabolismHPOHP:0032245
- Frequent (30% to 79% of cases)
- Abnormality of cytokine secretionHPOHP:0011113
- Frequent (30% to 79% of cases)
- Biliary hyperplasiaHPOHP:0006560
- Frequent (30% to 79% of cases)
- Elevated circulating alkaline phosphatase concentrationHPOHP:0003155
- Frequent (30% to 79% of cases)
Show the remaining 10
- Premature birthHPOHP:0001622
- Frequent (30% to 79% of cases)
- Small for gestational ageHPOHP:0001518
- Frequent (30% to 79% of cases)
- SplenomegalyHPOHP:0001744
- Frequent (30% to 79% of cases)
- Villous atrophyHPOHP:0011473
- Frequent (30% to 79% of cases)
- CholelithiasisHPOHP:0001081
- Occasional (5% to 29% of cases)
- CirrhosisHPOHP:0001394
- Occasional (5% to 29% of cases)
Where it sits
- A kind of
Other names
1 name
Resolves to: parenteral nutrition-associated cholestasis
- Also called
- PNAC