paraneoplastic cerebellar degeneration
MONDO:0044877Mondo
Findings
No curated finding names paraneoplastic cerebellar degeneration yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A rare, immune-mediated disorder characterized by cerebellar degeneration due to the presence of an often undetected malignancy (usually carcinoma or lymphoma) in an anatomic site other than the cerebellum. Signs and symptoms include progressive ataxia, dysarthria, and nystagmus.
Definition from the Mondo Disease Ontology (MONDO:0044877), read 2026-09-29. CC BY 4.0.
Features
24 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- AtaxiaHPOHP:0001251
- Frequent (30% to 79% of cases)
- CSF oligoclonal immunoglobulin G bandsHPOHP:6000397
- Frequent (30% to 79% of cases)
- CSF pleocytosisHPOHP:0012229
- Frequent (30% to 79% of cases)
- Increased CSF protein concentrationHPOHP:0002922
- Frequent (30% to 79% of cases)
- Anti-CV2/CRMP5 antibody positivityHPOHP:5000006
- Occasional (5% to 29% of cases)
- Anti-Hu antibody positivityHPOHP:5000016
- Occasional (5% to 29% of cases)
- Anti-mGluR1 antibodyHPOHP:5000024
- Occasional (5% to 29% of cases)
- Anti-Ri antibodyHPOHP:5000030
- Occasional (5% to 29% of cases)
- Anti-Tr/DNER antibodyHPOHP:5000034
- Occasional (5% to 29% of cases)
- Anti-Yo antibody positivityHPOHP:5000037
- Occasional (5% to 29% of cases)
- Cerebellar atrophyHPOHP:0001272
- Occasional (5% to 29% of cases)
- Cognitive impairmentHPOHP:0100543
- Occasional (5% to 29% of cases)
Show the remaining 12
- DiplopiaHPOHP:0000651
- Occasional (5% to 29% of cases)
- DysarthriaHPOHP:0001260
- Occasional (5% to 29% of cases)
- DysphagiaHPOHP:0002015
- Occasional (5% to 29% of cases)
- HeadacheHPOHP:0002315
- Occasional (5% to 29% of cases)
- Hodgkin lymphomaHPOHP:0012189
- Occasional (5% to 29% of cases)
- Low-grade feverHPOHP:0011134
- Occasional (5% to 29% of cases)