palmoplantar keratoderma-spastic paralysis syndrome
MONDO:0016353Mondo
Findings
No curated finding names palmoplantar keratoderma-spastic paralysis syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Features
12 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormal fingernail morphologyHPOHP:0001231
- Very frequent (80% to 99% of cases)
- Abnormal toenail morphologyHPOHP:0008388
- Very frequent (80% to 99% of cases)
- EMG abnormalityHPOHP:0003457
- Very frequent (80% to 99% of cases)
- Gait disturbanceHPOHP:0001288
- Very frequent (80% to 99% of cases)
- Muscle flaccidityHPOHP:0010547
- Very frequent (80% to 99% of cases)
- Pain insensitivityHPOHP:0007021
- Very frequent (80% to 99% of cases)
- Palmoplantar keratodermaHPOHP:0000982
- Very frequent (80% to 99% of cases)
- Peripheral neuropathyHPOHP:0009830
- Very frequent (80% to 99% of cases)
- Pes cavusHPOHP:0001761
- Very frequent (80% to 99% of cases)
- Thickened skinHPOHP:0001072
- Very frequent (80% to 99% of cases)
- HemiplegiaHPOHP:0002301
- Frequent (30% to 79% of cases)
- SpasticityHPOHP:0001257
- Frequent (30% to 79% of cases)
Where it sits
Other names
2 names
Resolves to: palmoplantar keratoderma-spastic paralysis syndrome
- Also called
- palmoplantar hyperkeratosis-spastic paralysis syndromePowell-Venencie-Gordon syndrome