OSLAM syndrome
MONDO:0008139Mondo
Findings
No curated finding names OSLAM syndrome yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
OSLAM syndrome is characterized by the association of osteosarcoma, limb anomalies (clinodactyly with brachymesophalangy, bilateral radioulnar synostosis and absence of one digital ray of the foot) and red cell macrocytosis without anemia.
Definition from the Mondo Disease Ontology (MONDO:0008139), read 2026-09-29. CC BY 4.0.
Features
7 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Abnormality of neutrophilsHPOHP:0001874
- Very frequent (80% to 99% of cases)
- Carious teethHPOHP:0000670
- Very frequent (80% to 99% of cases)
- Increased mean corpuscular volumeHPOHP:0005518
- Very frequent (80% to 99% of cases)
- OsteosarcomaHPOHP:0002669
- Very frequent (80% to 99% of cases)
- Short statureHPOHP:0004322
- Frequent (30% to 79% of cases)
- Clinodactyly of the 5th fingerHPOHP:0004209
- Occasional (5% to 29% of cases)
- Radioulnar synostosisHPOHP:0002974
- Occasional (5% to 29% of cases)
Where it sits
Other names
1 name
Resolves to: OSLAM syndrome
- Also called
- osteosarcoma-limb anomalies-erythroid macrocytosis syndrome