normal pressure hydrocephalus
Findings
No curated finding names normal pressure hydrocephalus yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see gait disorders, neurologic), progressive intellectual decline, and urinary incontinence. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of csf including subarachnoid hemorrhage, chronic meningitis, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)
Definition from the Mondo Disease Ontology (MONDO:0009366), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal dominant inheritance
HPO, annotations 2026-09-02
Features
1 feature
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Normal pressure hydrocephalusHPOHP:0002343
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- CFAP43HGNC:26684
- Limited · Ambry Genetics · Autosomal dominant · 2019
- Disputed Evidence · ClinGen · Autosomal dominant · 2026
Where it sits
Other names
3 names
Resolves to: normal pressure hydrocephalus
- Also called
- chronic adult hydrocephalushydrocephalus, normal pressure, 1NPH