nonsyndromic congenital nail disorder 1
Findings
No curated finding names nonsyndromic congenital nail disorder 1 yet. Everything below is reference data from Mondo, HPO and GenCC, not evidence about what affects it.
Definition
Nail dysplasia is an idiopathic nail dystrophy, beginning in early childhood, and characterized by excessive longitudinal striations and loss of nail luster affecting all 20 nails.
Definition from the Mondo Disease Ontology (MONDO:0008060), read 2026-09-29. CC BY 4.0.
- Inheritance
- Autosomal recessive inheritance
- Onset and course
- Congenital onset
HPO, annotations 2026-09-02
Features
19 features
What the disease is reported to present with, and how often among people who have it — never how often a feature means the disease. HPO, annotations 2026-09-02.
- Nail dysplasiaHPOHP:0002164
- 3 of 3 reported patients
- OnychauxisHPOHP:0012542
- 3 of 3 reported patients
- OnycholysisHPOHP:0001806
- 3 of 3 reported patients
- Nail dystrophyHPOHP:0008404
- Very frequent (80% to 99% of cases)
- Abnormal periungual morphologyHPOHP:0100803
- Frequent (30% to 79% of cases)
- Concave nailHPOHP:0001598
- Frequent (30% to 79% of cases)
- Fingernail dysplasiaHPO
Show the remaining 7
- Patchy alopeciaHPOHP:0002232
- Occasional (5% to 29% of cases)
- Toenail dysplasiaHPOHP:0100797
- Occasional (5% to 29% of cases)
- Amyloid depositionHPOHP:0011034
- Very rare (1% to 4% of cases)
- Atopic dermatitisHPOHP:0001047
- Very rare (1% to 4% of cases)
- Autoimmune thrombocytopeniaHPOHP:0001973
- Very rare (1% to 4% of cases)
- IchthyosisHPOHP:0008064
- Very rare (1% to 4% of cases)
Genes
1 gene
Germline variants in the gene encoding each protein, as classified by GenCC submitters, each in their own words. Limited, disputed and refuted submissions are listed too.
- FZD6HGNC:4044
- Definitive · G2P · Autosomal recessive · 2015
Where it sits
- A kind of
Other names
8 names
Resolves to: nonsyndromic congenital nail disorder 1
- Also called
- FZD6 inherited isolated nail anomalyinherited isolated nail anomaly caused by mutation in FZD6nail disorder, nonsyndromic congenital, type 10nonsyndromic congenital nail disorder 10nonsyndromic congenital nail disorder type 1nonsyndromic congenital nail disorder type 10onychodystrophy totalistwenty-nail dystrophy